A bullet penetration system is featured, in which bullets deal less damage when they hit enemies through structures. The environments of the game feature a layered material system, in which environmental objects of different materials show different reactions to player's attack. Like Tom Clancy's Rainbow Six Siege, the game features a destruction system that allows players to break structures by planting explosives on them or to make bullet holes on walls by shooting it. Voice and text chat are supported to satisfy this need. This risk and reward system makes communication between teammates key to completing Incursions successfully. Should an Operator be downed, they will enter the MIA status and cannot be chosen from again until they are rescued. Players will only receive one life per Incursion. REACT Tech is equipment that players can select before entering an Incursion in order to help handle certain situations or to compliment the Operators chosen by their teammates. Only one Operator may be chosen for an Incursion and can be upgraded through subsequent playthroughs. Deploying in these zones for a mission is known as an Incursion. Tom Clancy's Rainbow Six Extraction tasks a one-to-three-player team of Operators that must work together to complete various tasks within Active Containment Zones.

As the Archæans grow stronger, REACT must enter these zones to gather any information they can in order to find a way to stop them.

Rainbow established a new division, the Rainbow Exogenous Analysis & Containment Team (REACT) and set up containment zones around afflicted areas. Over the years, the Parasite has adapted to Earth and have evolved into the Archæans. Most notably: New Mexico, New York City, San Francisco, and Alaska. Several years after the 2018 outbreak in Truth or Consequences, New Mexico, the Chimera Parasite broke containment and subsequently spread to other areas in the United States.

Tom clancy extraction